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Early clinical data suggests higher rates of gastrointestinal side effects overall, with both constipation and diarrhea being common, sometimes alternating in the same user

For patients requiring additional glycemic lowering, the dose can be further up-titrated to 14 mg once daily after taking the 7 mg dose for at least 30 days

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Data for GST, CAT, SOD, and GPX were obtained from the INTERVAL study (Table 1